Oral Microbiome Testing & the Future of Perio Treatment | Dr. Ed Zuckerberg

Dr. Ed Zuckerberg tested his own saliva before and after a cleaning: three weeks later, his P. gingivalis levels were right back where they started. He explains why, how P. gingivalis is linked to heart disease, diabetes and Alzheimer's, why RNA-based saliva tests tell you more than DNA tests, and the new perio therapies coming next. In this episode: - The perio pyramid: from early colonizers to the "red zone" bacteria - How P. gingivalis toxins can cross the blood-brain barrier - The 1995 antibody study that kept P. gingivalis away for nine months - New research on P. gingivalis, heart disease and diabetes - His own saliva test results before and after scaling and root planing - Why RNA tells you more than DNA in saliva testing - Custom probiotics, senolytics and research on regrowing bone - Why patients say no to perio treatment, and how education changes that Plus dental news: the Colorado dentist found guilty, McDonald's says Grimace is a taste bud, and the latest on fluoride supplements. Dr. Ed Zuckerberg graduated from NYU College of Dentistry in 1978 and practiced in Brooklyn and Dobbs Ferry, New York, until 2013. He lectures on the oral-systemic connection, is a venture partner at Revere Partners, the first independent venture fund for oral health, and is chief dental officer at Viome. He treats patients part-time in Cupertino, California. Chapters: 0:00 Intro 2:16 Chad's phone mix-up 3:35 Patients who forget their appliances 5:09 Insurance recoupments 8:42 News: the Colorado dentist found guilty 9:43 News: Grimace is a taste bud 12:34 News: fluoride supplements and a quiet August 14:16 Introducing Dr. Ed Zuckerberg 16:48 Brooklyn, and 23 years practicing at home 19:18 The move to California 21:09 Howard Farran and his second career 23:26 The pandemic and Revere Partners 27:28 Keystone Bio and P. gingivalis 28:54 The patients who made him wonder 31:03 What dental school taught us about the mouth-body link 32:46 The perio pyramid: yellow, orange and red bacteria 34:48 How P. gingivalis toxins reach the brain 37:47 The 1995 antibody study 40:11 P. gingivalis and heart disease 42:21 P. gingivalis and diabetes 43:34 His own saliva tests before and after a cleaning 46:19 Why RNA tells you more than DNA 48:57 What a saliva report shows 50:56 Today's perio treatment options 52:01 Custom probiotics 53:32 Regrowing bone in dogs, and maybe people 56:19 Why patients say no to perio treatment 57:16 Senolytics and periodontal aging 59:24 Supplements for perio health 1:03:07 Targeting gingipains with a pill 1:07:28 Should patients hear this too? 1:09:53 Dentistry as primary care for the mouth 1:11:28 Closing 🎧 Listen to the podcast: Apple Podcasts: https://podcasts.apple.com/us/podcast/dentists-in-the-know/id1543254763 Spotify: https://open.spotify.com/show/2Elfj6LX0hCUyp0AgdTsij 📺 Make sure you subscribe to catch new episodes live every Wednesday at 8pm ET! https://www.youtube.com/@dentistsintheknow 🌟 Stay up to date on all the latest dental trends when you follow the DINKs: https://fanflet.com/dinks/social-2